| Name
|
 UBE2F
|
| Full Name |
NEDD8-conjugating enzyme UBE2F |
| Synonyms |
NEDD8 carrier protein UBE2F, NEDD8 protein ligase UBE2F, NEDD8-conjugating enzyme 2, RING-type E3 NEDD8 transferase UBE2F, Ubiquitin-conjugating enzyme E2 F | NCE2 |
| Primary ID |
Q969M7 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
1 |
| Inhibitors |
pevonedistat
|
| Function |
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5. |
3.0
chemical inhibition