3.0
Summary
| Name |  TOP1MT
|
| Full Name | DNA topoisomerase I, mitochondrial |
| Synonyms | TOP1mt | |
| Primary ID | Q969P6 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Inhibitors | irinotecan; topotecan |
| Function | Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). |
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