Summary

Name RNF166
Full Name E3 ubiquitin-protein ligase RNF166
Synonyms RN166_HUMAN |
Primary ID Q96A37
Links - -
Type protein
Relations 1
Function E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates (PubMed:27880896). In turn, participates in different biological processes including interferon production or autophagy (PubMed:26456228, PubMed:27880896). Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6 (PubMed:26456228). Plays also a role in the early recruitment of autophagy adapters to bacteria (PubMed:27880896). Mediates 'Lys-29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication (PubMed:27880896).

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Relations

Regulator Mechanism target score ℹ
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination RNF166 0.2
Publications: 1 Organism: Homo Sapiens