Summary

Name PTH2
Full Name Tuberoinfundibular peptide of 39 residues
Synonyms TIP39, Parathyroid hormone 2 | TIP39, TIPF39
Primary ID Q96A98
Links - -
Type protein
Relations 1
Function Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding PTH2R 0.756
Publications: 1 Organism: Homo Sapiens
Tissue: Brain, Kidney