Summary

Name NUS1
Full Name Dehydrodolichyl diphosphate synthase complex subunit NUS1
Synonyms Di-trans,poly-cis-decaprenylcistransferase, Nogo-B receptor, NgBR, Nuclear undecaprenyl pyrophosphate synthase 1 homolog | C6orf68, NGBR
Primary ID Q96E22
Links - -
Type protein
Relations 1
Function With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:21572394, PubMed:25066056, PubMed:28842490, PubMed:32817466). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length (PubMed:32817466). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator (PubMed:16835300).

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Relations

Regulator Mechanism target score ℹ
+ NUS1form complex img/form-complex.png binding NgBR/DHDDS complex 0.768
Publications: 1 Organism: Homo Sapiens