Summary

Name SGF29
Full Name SAGA-associated factor 29
Synonyms Coiled-coil domain-containing protein 101, SAGA complex-associated factor 29 | CCDC101
Primary ID Q96ES7
Links - -
Type protein
Relations 1
Function Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581).

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Relations

Regulator Mechanism target score ℹ
+ SGF29form complex img/form-complex.png binding SAGA complex 0.2
Publications: 1 Organism: Homo Sapiens