Summary

Name THOC1
Full Name THO complex subunit 1
Synonyms Tho1, Nuclear matrix protein p84, p84N5, hTREX84 | HPR1
Primary ID Q96FV9
Links - -
Type protein
Relations 1
Function Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation.

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Relations

Regulator Mechanism target score ℹ
+ THOC1form complex img/form-complex.png binding TREX complex 0.913
Publications: 1 Organism: Homo Sapiens