Summary

Name KIF20B
Full Name Kinesin-like protein KIF20B
Synonyms Cancer/testis antigen 90, CT90, Kinesin family member 20B, Kinesin-related motor interacting with PIN1, M-phase phosphoprotein 1, MPP1 | KRMP1, MPHOSPH1
Primary ID Q96Q89
Links - -
Type protein
Relations 2
Function Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation KIF20B 0.422
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Plus-end directed sliding movement 0.7
Publications: 1 Organism: Homo Sapiens