Summary

Name PNKP
Full Name Bifunctional polynucleotide phosphatase/kinase
Synonyms DNA 5'-kinase/3'-phosphatase, Polynucleotide kinase-3'-phosphatase
Primary ID Q96T60
Links - -
Type protein
Relations 4
Function Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation PNKP 0.476
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PNKP 0.636
Publications: 2 Organism: Homo Sapiens