Relation Results

Summary

Name PNKP
Full Name Bifunctional polynucleotide phosphatase/kinase
Synonyms DNA 5'-kinase/3'-phosphatase, Polynucleotide kinase-3'-phosphatase
Primary ID Q96T60
Links - -
Type protein
Relations 4
Function Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathway ...
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Type: Score: Layout: SPV 
0.4660.648ATMPNKPPRKDC

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ ATMup-regulates img/direct-activation.png phosphorylation PNKP 0.466
Identifier Residue Sequence Organism Cell Line
SIGNOR-176008 Ser114 EETRTPEsQPDTPPG Homo sapiens
pmid sentence
We demonstrate that pnkp is phosphorylated by the dna-dependent protein kinase (dna-pk) and ataxia-telangiectasia mutated (atm) in vitro. The major phosphorylation site for both kinases was serine 114, with serine 126 being a minor site. Purified pnkp protein with mutation of serines 114 and 126 had decreased dna kinase and dna phosphatase activities and reduced affinity for dna in vitro.
Identifier Residue Sequence Organism Cell Line
SIGNOR-176012 Ser126 PPGTPLVsQDEKRDA Homo sapiens
pmid sentence
We demonstrate that pnkp is phosphorylated by the dna-dependent protein kinase (dna-pk) and ataxia-telangiectasia mutated (atm) in vitro. The major phosphorylation site for both kinases was serine 114, with serine 126 being a minor site. Purified pnkp protein with mutation of serines 114 and 126 had decreased dna kinase and dna phosphatase activities and reduced affinity for dna in vitro.
Publications: 2 Organism: Homo Sapiens
+ PRKDCup-regulates img/direct-activation.png phosphorylation PNKP 0.648
Identifier Residue Sequence Organism Cell Line
SIGNOR-176016 Ser114 EETRTPEsQPDTPPG Homo sapiens
pmid sentence
We demonstrate that pnkp is phosphorylated by the dna-dependent protein kinase (dna-pk) and ataxia-telangiectasia mutated (atm) in vitro. The major phosphorylation site for both kinases was serine 114, with serine 126 being a minor site. Purified pnkp protein with mutation of serines 114 and 126 had decreased dna kinase and dna phosphatase activities and reduced affinity for dna in vitro.
Identifier Residue Sequence Organism Cell Line
SIGNOR-176020 Ser126 PPGTPLVsQDEKRDA Homo sapiens
pmid sentence
We demonstrate that pnkp is phosphorylated by the dna-dependent protein kinase (dna-pk) and ataxia-telangiectasia mutated (atm) in vitro. The major phosphorylation site for both kinases was serine 114, with serine 126 being a minor site. Purified pnkp protein with mutation of serines 114 and 126 had decreased dna kinase and dna phosphatase activities and reduced affinity for dna in vitro.
Publications: 2 Organism: Homo Sapiens
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