Relation Results

Summary

Name PSMD1
Full Name 26S proteasome non-ATPase regulatory subunit 1
Synonyms 26S proteasome regulatory subunit RPN2, 26S proteasome regulatory subunit S1, 26S proteasome subunit p112 |
Primary ID Q99460
Links - -
Type protein
Relations 2
Inhibitors bortezomib
Function Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key ...
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Type: Score: Layout: SPV 
0.9050.8PSMD126S Proteasomebortezomib

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Relations
Regulator
Mechanism
target
score ℹ
+ PSMD1form complex img/form-complex.png binding 26S Proteasome 0.905
Identifier Residue Sequence Organism Cell Line
SIGNOR-263354 Homo sapiens HEK-293 Cell
pmid sentence
Here, we report near-atomic resolution cryo-EM structures of the activated human proteasome|The proteasome is composed of a 28-subunit barrel-shaped core particle (CP) and two 19- subunit regulatory particles (RP)5–8 capped at both sides of the CP|Human proteasomes were purified through affinity chromatography on a large scale from a stable HEK293 cell line
Publications: 1 Organism: Homo Sapiens
+ bortezomibdown-regulates activity img/direct_inhibition.png chemical inhibition PSMD1 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-259312 Homo sapiens Myeloma Cell
pmid sentence
Proteasome inhibition is a modern and surprisingly successful approach how to cancer treatment. Bortezomib (Velcade®) is a first-in-class proteasome inhibitor and has been approved for first-line treatment of multiple myeloma and second-line treatment of mantle cell lymphoma.
Publications: 1 Organism: Homo Sapiens
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