Summary

Name BARD1
Full Name BRCA1-associated RING domain protein 1
Synonyms BARD-1
Primary ID Q99728
Links - -
Type protein
Relations 4
Function E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.

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Relations

Regulator Mechanism target score ℹ
+ BARD1form complex img/form-complex.png binding BRCA1-BARD1 complex 0.786
Publications: 1
+ BARD1down-regulates quantity img/direct_inhibition.png ubiquitination ESR1
Publications: 1 Organism: Homo Sapiens
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination BARD1 0.2
Publications: 1 Organism: Homo Sapiens
+ BARD1up-regulates img/direct-activation.png binding BRCA1 0.786
Publications: 1 Organism: Homo Sapiens