4.0
Summary
| Name |  NPAS2
|
| Full Name | Neuronal PAS domain-containing protein 2 |
| Synonyms | Neuronal PAS2, Basic-helix-loop-helix-PAS protein MOP4, Class E basic helix-loop-helix protein 9, bHLHe9, Member of PAS protein 4, PAS domain-containing protein 4 | BHLHE9, MOP4, PASD4 |
| Primary ID | Q99743 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Pathways | Circadian clock |
| Function | Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | RORA | up-regulates quantity by expression 
transcriptional regulation
|
NPAS2 | 0.665 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Circadian clock | |||
| + | NR1D1 | down-regulates quantity by repression 
transcriptional regulation
|
NPAS2 | 0.632 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Circadian clock | |||
| + | NPAS2 | form complex 
binding
|
BMAL1/NPAS2 | 0.539 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Circadian clock | |||