Relation Results

Summary

Name ARID3A
Full Name AT-rich interactive domain-containing protein 3A
Synonyms ARID domain-containing protein 3A, B-cell regulator of IgH transcription, Bright, Dead ringer-like protein 1, E2F-binding protein 1 | DRIL1, DRIL3, DRX, E2FBP1
Primary ID Q99856
Links - -
Type protein
Relations 3
Function Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation.

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Type: Score: Layout: SPV 
0.3560.20.2GTF2IARID3AImmunoglobulin delta heavy chainImmunoglobulin mu heavy chain

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Relations
Regulator
Mechanism
target
score ℹ
+ GTF2Iup-regulates activity img/direct-activation.png binding ARID3A 0.356
Identifier Residue Sequence Organism Cell Line
SIGNOR-268533 Homo sapiens B-lymphocyte
pmid sentence
In this work, we show that TFII-I directly interacts with human Bright through amino acids in Bright's protein interaction domain and that specific tyrosine residues of TFII-I are essential for Bright-induced activity of an immunoglobulin reporter gene. Moreover, inhibition of TFII-I function in a B-cell line resulted in decreased heavy-chain transcript levels.
Publications: 1 Organism: Homo Sapiens
+ ARID3Aup-regulates quantity by expression img/direct-activation.png transcriptional regulation Immunoglobulin delta heavy chain 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268531 Homo sapiens B-lymphocyte
pmid sentence
In this work, we show that TFII-I directly interacts with human Bright through amino acids in Bright's protein interaction domain and that specific tyrosine residues of TFII-I are essential for Bright-induced activity of an immunoglobulin reporter gene. Moreover, inhibition of TFII-I function in a B-cell line resulted in decreased heavy-chain transcript levels.| Figure ​3 shows that both anti-Bright and anti-TFII-I precipitated the bf150 Bright binding site from the B-cell line but not from a T-cell line that contains but does not express the V1 gene.
Publications: 1 Organism: Homo Sapiens
+ ARID3Aup-regulates quantity by expression img/direct-activation.png transcriptional regulation Immunoglobulin mu heavy chain 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268532 Homo sapiens B-lymphocyte
pmid sentence
In this work, we show that TFII-I directly interacts with human Bright through amino acids in Bright's protein interaction domain and that specific tyrosine residues of TFII-I are essential for Bright-induced activity of an immunoglobulin reporter gene. Moreover, inhibition of TFII-I function in a B-cell line resulted in decreased heavy-chain transcript levels.| Figure ​3 shows that both anti-Bright and anti-TFII-I precipitated the bf150 Bright binding site from the B-cell line but not from a T-cell line that contains but does not express the V1 gene.
Publications: 1 Organism: Homo Sapiens
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