3.0
Summary
| Name |  HOPX
|
| Full Name | Homeodomain-only protein |
| Synonyms | Lung cancer-associated Y protein, Not expressed in choriocarcinoma protein 1, Odd homeobox protein 1 | HOD, HOP, LAGY, NECC1, OB1 |
| Primary ID | Q9BPY8 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (PubMed:27708256). |
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transcriptional regulation