Relation Results

Summary

Name FYCO1
Full Name FYVE and coiled-coil domain-containing protein 1
Synonyms Zinc finger FYVE domain-containing protein 7 | ZFYVE7
Primary ID Q9BQS8
Links - -
Type protein
Relations 3
Function May mediate microtubule plus end-directed vesicle transport.

Viewer

Type: Score: Layout: SPV 
0.5320.3510.577FYCO1MAP1LC3BKLC2MAP1LC3A

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations
Regulator
Mechanism
target
score ℹ
+ FYCO1up-regulates activity img/direct-activation.png binding MAP1LC3B 0.532
Identifier Residue Sequence Organism Cell Line
SIGNOR-260597 Homo sapiens HEK-293 Cell
pmid sentence
The preferential binding to LC3A and -B was confirmed in vivo by co-immunoprecipitation experiments of Myc-tagged FYCO1 and GFP fusions of human ATG8 family pro-teins expressed in HEK293 cells (Fig. 2B). GFP-LC3A and GFP-LC3B were efficiently co-precipitated with Myc-FYCO1,whereas GFP-LC3C, GFP-GABARAP, GFP-GABARAPL1 and-L2 were not. The effects we see on late steps of basal autophagy on mutation of the FYCO1 LIR motif correlate with a role of FYCO1 in regulating kinesin-mediated transport of LC3-positive autophagic structures.
Publications: 1 Organism: Homo Sapiens
+ KLC2up-regulates activity img/direct-activation.png binding FYCO1 0.351
Identifier Residue Sequence Organism Cell Line
SIGNOR-260599 Homo sapiens HeLa Cell
pmid sentence
Interestingly, bead capture assays indicated that the middle part of FYCO1 (residues 585–1233) interacts directly with the KLC2 light chain of kinesin 1 (Fig. 3a and Extended Data Fig. 7a, b). Residues 735–773 of FYCO1 were found to be necessary for its kinesin-1 binding (Fig. 3c and Extended Data Fig. 7b, c), and FYCO1(Δ735–773)-positive LEs failed to translocate to the cell periphery (Extended Data Fig. 7e).
Publications: 1 Organism: Homo Sapiens
+ FYCO1up-regulates activity img/direct-activation.png binding MAP1LC3A 0.577
Identifier Residue Sequence Organism Cell Line
SIGNOR-260598 Homo sapiens HEK-293 Cell
pmid sentence
The preferential binding to LC3A and -B was confirmed in vivo by co-immunoprecipitation experiments of Myc-tagged FYCO1 and GFP fusions of human ATG8 family pro-teins expressed in HEK293 cells (Fig. 2B). GFP-LC3A and GFP-LC3B were efficiently co-precipitated with Myc-FYCO1,whereas GFP-LC3C, GFP-GABARAP, GFP-GABARAPL1 and-L2 were not. The effects we see on late steps of basal autophagy on mutation of the FYCO1 LIR motif correlate with a role of FYCO1 in regulating kinesin-mediated transport of LC3-positive autophagic structures.
Publications: 1 Organism: Homo Sapiens
a simple tooltip