| + |
TBK1 | up-regulates quantity 
phosphorylation
|
SIKE1 |
0.718 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273815 |
Ser133 |
PVLKAHQsHSAEIES |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23649622 |
TBK1 phosphorylates SIKE on six serine residues that mimic the IRF3 phosphorylation sequence.Serines are listed from left to right: 133, 185, 187, 188, 190, and 198. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273813 |
Ser185 |
KELRELLsISSESLQ |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23649622 |
TBK1 phosphorylates SIKE on six serine residues that mimic the IRF3 phosphorylation sequence.TBK1-SIKE interactions were modulated by SIKE phosphorylation, clustered in the C-terminal portion of SIKE (Ser-133, -185, -187, -188, -190, and -198). Here, we describe the mechanism by which suppressor of IKKε (SIKE) inhibits TBK1-mediated phosphorylation of interferon regulatory factor 3 (IRF3), which is essential to type I interferon production. Kinetic analyses showed that SIKE not only inhibits IRF3 phosphorylation but is also a high affinity TBK1 substrate. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273814 |
Ser187 |
LRELLSIsSESLQAR |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23649622 |
TBK1 phosphorylates SIKE on six serine residues that mimic the IRF3 phosphorylation sequence.Serines are listed from left to right: 133, 185, 187, 188, 190, and 198. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273816 |
Ser188 |
RELLSISsESLQARK |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23649622 |
TBK1 phosphorylates SIKE on six serine residues that mimic the IRF3 phosphorylation sequence.Serines are listed from left to right: 133, 185, 187, 188, 190, and 198. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273817 |
Ser190 |
LLSISSEsLQARKEN |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23649622 |
TBK1 phosphorylates SIKE on six serine residues that mimic the IRF3 phosphorylation sequence.Serines are listed from left to right: 133, 185, 187, 188, 190, and 198. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273818 |
Ser198 |
LQARKENsMDTASQA |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23649622 |
TBK1 phosphorylates SIKE on six serine residues that mimic the IRF3 phosphorylation sequence.Serines are listed from left to right: 133, 185, 187, 188, 190, and 198. |
|
| Publications: |
6 |
Organism: |
Homo Sapiens |
| + |
TBK1 | down-regulates quantity 
phosphorylation
|
SIKE1 |
0.718 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280152 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23649622 |
Mechanism of endogenous regulation of the type I interferon response by suppressor of I\u03baB kinase epsilon (SIKE), a novel substrate of TANK-binding kinase 1 (TBK1).|TBK1 phosphorylation of IRF3 and SIKE displayed negative cooperativity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
SIKE1
- 
- 