Relation Results

Summary

Name PCGF6
Full Name Polycomb group RING finger protein 6
Synonyms Mel18 and Bmi1-like RING finger, RING finger protein 134 | MBLR, RNF134
Primary ID Q9BYE7
Links - -
Type protein
Relations 2
Function Transcriptional repressor (PubMed:12167161). May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase (PubMed:17320162). Com ...
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Type: Score: Layout: SPV 
0.3060.2CDK7PCGF6Ub:E2

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ CDK7 img/unknown.png phosphorylation PCGF6 0.306
Identifier Residue Sequence Organism Cell Line
SIGNOR-250769 Ser30 LPPPPPVsPPALTPA in vitro
pmid sentence
In addition, we find that serine 32 of MBLR is specifically phosphorylated during mitosis, most likely by CDK7, a component of the basal transcriptional machinery. | These results indicate that, at least in vitro, MBLR is a substrate for CDK7 phosphorylation.
Publications: 1 Organism: In Vitro
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination PCGF6 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271037 Homo sapiens
pmid sentence
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t
Publications: 1 Organism: Homo Sapiens
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