4.0
Summary
| Name |  TBL1XR1View Modifications |
| Full Name | F-box-like/WD repeat-containing protein TBL1XR1 |
| Synonyms | Nuclear receptor corepressor/HDAC3 complex subunit TBLR1, TBL1-related protein 1, Transducin beta-like 1X-related protein 1 | IRA1, TBLR1 |
| Primary ID | Q9BZK7 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCD | up-regulates activity 
phosphorylation
|
TBL1XR1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TBL1XR1 | down-regulates 
ubiquitination
|
BCL3 | 0.402 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TBL1XR1 | up-regulates
binding
|
AR | 0.395 |
| Publications: | 1 | Organism: | Homo Sapiens | |