Summary

Name SPEF2
Full Name Sperm flagellar protein 2
Synonyms Protein KPL2 | KIAA1770, KPL2
Primary ID Q9C093
Links - -
Type protein
Relations 0
Function Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis (PubMed:31278745, PubMed:31151990, PubMed:31048344). Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation (By similarity).

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