Relation Results

Summary

Name TTYH3
Full Name Protein tweety homolog 3
Synonyms hTTY3 | KIAA1691
Primary ID Q9C0H2
Links - -
Type protein
Relations 1
Function Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. {ECO:0000269|PubMed:15010458}.

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Type: Score: Layout: SPV 
0.2NEDD4LTTYH3

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Relations
Regulator
Mechanism
target
score ℹ
+ NEDD4Ldown-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination TTYH3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-272633 Homo sapiens HEK-293 Cell
pmid sentence
Our data indicate that Nedd4-2 binds to two family members, TTYH2 and TTYH3, which contain consensus PY ((L/P)PXY) binding sites for HECT type E3 ubiquitin ligases, but not to TTYH1, which lacks this motif. Consistently, Nedd4-2 ubiquitinates both TTYH2 and TTYH3. Importantly, we have shown that endogenous TTYH2 and Nedd4-2 are binding partners and demonstrated that the TTYH2 PY motif is essential for these interactions. We have also shown that Nedd4-2-mediated ubiquitination of TTYH2 is a critical regulator of cell surface and total cellular levels of this protein. 
Publications: 1 Organism: Homo Sapiens
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