Summary

Name SENP3
Full Name Sentrin-specific protease 3
Synonyms SUMO-1-specific protease 3, Sentrin/SUMO-specific protease SENP3 | SSP3, SUSP3
Primary ID Q9H4L4
Links - -
Type protein
Relations 1
Function Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.

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Relations

Regulator Mechanism target score ℹ
+ SENP3form complex img/form-complex.png binding Rix1 complex 0.796
Publications: 1 Organism: Homo Sapiens