Relation Results

Summary

Name HPS4
Full Name Hermansky-Pudlak syndrome 4 protein
Synonyms Light-ear protein homolog | KIAA1667
Primary ID Q9NQG7
Links - -
Type protein
Relations 2
Function Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, conv ...
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Type: Score: Layout: SPV 
0.2930.752TFEBHPS4BLOC-3

Relations

Regulator
Mechanism
target
score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HPS4 0.293
Identifier Residue Sequence Organism Cell Line
SIGNOR-276795
pmid sentence
Up-regulated proteins belonged to classes related to protein catabolism, including lysosomal and autophagic proteins (ATP6V1H, CAT, CTSB, CTSC, CTSL, CTSZ, LANCL2, GNS, and PLIN2), endosome/multivesicular body proteins (AP1G1, CHMP1B, CHMP2B, EEA1, RAB7A, and VPS35), Golgi proteins (COPB1 and GALNT5), and the proteasome (PSMA1-5, PSMB2-6, PSMC2-5, PSMD2, PMSD11, and PMSD14)
Publications: 1
+ form complex img/form-complex.png binding BLOC-3 0.752
Identifier Residue Sequence Organism Cell Line
SIGNOR-260692 Homo sapiens
pmid sentence
Two of these genes, HPS1 and HPS4, encode components of the biogenesis of lysosome-related organelles complex-3 (BLOC-3). Herein we show that recombinant HPS1-HPS4 produced in insect cells can be efficiently isolated as a 1:1 heterodimer.
Publications: 1 Organism: Homo Sapiens
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