Summary

Name KMT5A
Full Name N-lysine methyltransferase KMT5A
Synonyms H4-K20-HMTase KMT5A, Histone-lysine N-methyltransferase KMT5A, 2.1.1.43, Lysine N-methyltransferase 5A, Lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7, PR/SET07, SET domain-containing protein 8 | PRSET7, SET07, SET8, SETD8
Primary ID Q9NQR1
Links - -
Type protein
Relations 4
Function Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png dephosphorylation KMT5A
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png dephosphorylation KMT5A
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation KMT5A
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation KMT5A 0.23
Publications: 1 Organism: Homo Sapiens