Relation Results

Summary

Name ACSS2
Full Name Acetyl-coenzyme A synthetase, cytoplasmic
Synonyms EC 6.2.1.1, Acetate--CoA ligase, Acetyl-CoA synthetase, ACS, AceCS, Acetyl-CoA synthetase 1, AceCS1, Acyl-CoA synthetase short-chain family member 2, Acyl-activating enzyme, Propionate--CoA ligase, EC 6.2.1.17 | ACAS2
Primary ID Q9NR19
Links - -
Type protein
Relations 12
Function Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:10843999, PubMed:28003429). Acetate is the preferred substrate (PubMed:1084 ...
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Type: Score: Layout: SPV 
0.2740.2780.20.20.20.80.2640.20.80.80.20.2AMPKACSS2PRKAA1CTSAPPM1DMAP1LC3Bcoenzyme A(4-)GUSBGBAacetyl-CoA(4-)acetateBECN1LAMP1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ AMPKup-regulates activity img/direct-activation.png phosphorylation ACSS2 0.274
Identifier Residue Sequence Organism Cell Line
SIGNOR-271823 Ser659 PGLPKTRsGKIMRRV
pmid sentence
This translocation is mediated by AMP-activated protein kinase (AMPK)-dependent ACSS2 Ser659 phosphorylation and subsequent exposure of the nuclear localization signal of ACSS2 to KPNA1/importin α5 for binding. In the nucleus, ACSS2 forms a complex with TFEB (transcription factor EB) and utilizes the acetate generated from histone deacetylation to locally produce acetyl-CoA for histone acetylation in the promoter regions of TFEB target genes.
Publications: 1
+ PRKAA1up-regulates activity img/direct-activation.png phosphorylation ACSS2 0.278
Identifier Residue Sequence Organism Cell Line
SIGNOR-271822 Ser659 PGLPKTRsGKIMRRV
pmid sentence
This translocation is mediated by AMP-activated protein kinase (AMPK)-dependent ACSS2 Ser659 phosphorylation and subsequent exposure of the nuclear localization signal of ACSS2 to KPNA1/importin α5 for binding. In the nucleus, ACSS2 forms a complex with TFEB (transcription factor EB) and utilizes the acetate generated from histone deacetylation to locally produce acetyl-CoA for histone acetylation in the promoter regions of TFEB target genes.
Publications: 1
+ ACSS2up-regulates quantity by expression img/direct-activation.png transcriptional regulation CTSA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276550
pmid sentence
Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy|A chromatin immunoprecipitation (ChIP) assay with antibodies against TFEB or ACSS2 demonstrated that glucose deprivation results in the binding of TFEB (Figure 3D) and ACSS2 (Figure 3E) to the promoter regions of CTSA, GBA, GUSB, and LAMP1|These results indicated that TFEB and ACSS2 are mutually required for their binding to the promoter regions of lysosomal genes. In line with these findings, glucose deprivation induced mRNA (Figure 3F) and protein (Figure 3G) expression for these lysosomal genes, which was largely abrogated by knockin of ACSS2 mutants
Publications: 1
+ ACSS2up-regulates quantity by expression img/direct-activation.png transcriptional regulation PPM1D 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276560
pmid sentence
As expected, we found that glucose deprivation induced the binding of TFEB (Figure S4C) and ACSS2 (Figure S4D) to the promoter regions of MAP1LC3B, ATG3, and WIPI-1 as well as mRNA (Figure 3H) and protein (Figure 3I) expression of these genes;
Publications: 1
+ ACSS2up-regulates quantity by expression img/direct-activation.png transcriptional regulation MAP1LC3B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276562
pmid sentence
As expected, we found that glucose deprivation induced the binding of TFEB (Figure S4C) and ACSS2 (Figure S4D) to the promoter regions of MAP1LC3B, ATG3, and WIPI-1 as well as mRNA (Figure 3H) and protein (Figure 3I) expression of these genes;
Publications: 1
+ ACSS2down-regulates quantity img/direct_inhibition.png chemical modification coenzyme A(4-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-271828
pmid sentence
The gene encodes acetyl-CoA synthetase (ACS), the cytosolic enzyme that activates acetate so that it can be used for lipid synthesis or for energy generation. |The recombinant enzyme produced acetyl-CoA from acetate in a reaction that required ATP.
Publications: 1
+ ACSS2up-regulates quantity by expression img/direct-activation.png transcriptional regulation GUSB 0.264
Identifier Residue Sequence Organism Cell Line
SIGNOR-276554
pmid sentence
Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy|A chromatin immunoprecipitation (ChIP) assay with antibodies against TFEB or ACSS2 demonstrated that glucose deprivation results in the binding of TFEB (Figure 3D) and ACSS2 (Figure 3E) to the promoter regions of CTSA, GBA, GUSB, and LAMP1|These results indicated that TFEB and ACSS2 are mutually required for their binding to the promoter regions of lysosomal genes. In line with these findings, glucose deprivation induced mRNA (Figure 3F) and protein (Figure 3G) expression for these lysosomal genes, which was largely abrogated by knockin of ACSS2 mutants
Publications: 1
+ ACSS2up-regulates quantity by expression img/direct-activation.png transcriptional regulation GBA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276552
pmid sentence
Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy|A chromatin immunoprecipitation (ChIP) assay with antibodies against TFEB or ACSS2 demonstrated that glucose deprivation results in the binding of TFEB (Figure 3D) and ACSS2 (Figure 3E) to the promoter regions of CTSA, GBA, GUSB, and LAMP1|These results indicated that TFEB and ACSS2 are mutually required for their binding to the promoter regions of lysosomal genes. In line with these findings, glucose deprivation induced mRNA (Figure 3F) and protein (Figure 3G) expression for these lysosomal genes, which was largely abrogated by knockin of ACSS2 mutants
Publications: 1
+ ACSS2up-regulates quantity img/direct-activation.png chemical modification acetyl-CoA(4-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-271826
pmid sentence
The gene encodes acetyl-CoA synthetase (ACS), the cytosolic enzyme that activates acetate so that it can be used for lipid synthesis or for energy generation. |The recombinant enzyme produced acetyl-CoA from acetate in a reaction that required ATP.
Publications: 1
+ ACSS2down-regulates quantity img/direct_inhibition.png chemical modification acetate 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-271827
pmid sentence
The gene encodes acetyl-CoA synthetase (ACS), the cytosolic enzyme that activates acetate so that it can be used for lipid synthesis or for energy generation. |The recombinant enzyme produced acetyl-CoA from acetate in a reaction that required ATP.
Publications: 1
+ ACSS2up-regulates quantity by expression img/direct-activation.png transcriptional regulation BECN1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276561
pmid sentence
As expected, we found that glucose deprivation induced the binding of TFEB (Figure S4C) and ACSS2 (Figure S4D) to the promoter regions of MAP1LC3B, ATG3, and WIPI-1 as well as mRNA (Figure 3H) and protein (Figure 3I) expression of these genes;
Publications: 1
+ ACSS2up-regulates quantity by expression img/direct-activation.png transcriptional regulation LAMP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276556
pmid sentence
Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy|A chromatin immunoprecipitation (ChIP) assay with antibodies against TFEB or ACSS2 demonstrated that glucose deprivation results in the binding of TFEB (Figure 3D) and ACSS2 (Figure 3E) to the promoter regions of CTSA, GBA, GUSB, and LAMP1|These results indicated that TFEB and ACSS2 are mutually required for their binding to the promoter regions of lysosomal genes. In line with these findings, glucose deprivation induced mRNA (Figure 3F) and protein (Figure 3G) expression for these lysosomal genes, which was largely abrogated by knockin of ACSS2 mutants
Publications: 1
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