3.0
Summary
| Name |  ACSS2View Modifications |
| Full Name | Acetyl-coenzyme A synthetase, cytoplasmic |
| Synonyms | EC 6.2.1.1, Acetate--CoA ligase, Acetyl-CoA synthetase, ACS, AceCS, Acetyl-CoA synthetase 1, AceCS1, Acyl-CoA synthetase short-chain family member 2, Acyl-activating enzyme, Propionate--CoA ligase, EC 6.2.1.17 | ACAS2 |
| Primary ID | Q9NR19 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:10843999, PubMed:28003429). Acetate is the preferred substrate (PubMed:10843999, PubMed:28003429). Can also utilize propionate with a much lower affinity (By similarity). {ECO:0000250|UniProtKB:Q9QXG4, ECO:0000269|PubMed:10843999, ECO:0000269|PubMed:28003429}. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | AMPK | up-regulates activity 
phosphorylation
|
ACSS2 | 0.277 |
| Publications: | 1 | |||
| + | PRKAA1 | up-regulates activity
phosphorylation
|
ACSS2 | 0.281 |
| Publications: | 1 | |||
| + | ACSS2 | up-regulates quantity
chemical modification
|
acetyl-CoA(4-) | 0.8 |
| Publications: | 1 | |||
| + | ACSS2 | down-regulates quantity 
chemical modification
|
acetate | 0.8 |
| Publications: | 1 | |||
| + | ACSS2 | down-regulates quantity
chemical modification
|
coenzyme A(4-) | 0.8 |
| Publications: | 1 | |||