3.0
Summary
| Name |  CCDC88C
|
| Full Name | Protein Daple |
| Synonyms | Coiled-coil domain-containing protein 88C, Dvl-associating protein with a high frequency of leucine residues, hDaple, Hook-related protein 2, HkRP2 | DAPLE, KIAA1509 |
| Primary ID | Q9P219 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling (PubMed:26126266). Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling (PubMed:26126266). Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation (PubMed:26126266). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signaling (PubMed:26126266). Promotes apical constriction of cells via ARHGEF18 (PubMed:30948426). |
binding