| + |
PLK1 | down-regulates 
phosphorylation
|
ATXN10 |
0.365 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176122 |
Ser77 |
QVENLASsLQLITEC |
Homo sapiens |
|
| pmid |
sentence |
| 21857149 |
Phosphorylation of ataxin-10 by polo-like kinase 1 is required for cytokinesis. Plk1 phosphorylates ataxin-10 at s77 and t82 in vitro. we found that ataxin-10 is ubiquitinated, and is subject to proteasome-dependent degradation, which is delayed in the 2a mutant. We propose a model in which plk1 phosphorylation of ataxin-10 influences its degradation and cytokinesis |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176126 |
Thr82 |
ASSLQLItECFRCLR |
Homo sapiens |
|
| pmid |
sentence |
| 21857149 |
Phosphorylation of ataxin-10 by polo-like kinase 1 is required for cytokinesis. Plk1 phosphorylates ataxin-10 at s77 and t82 in vitro. we found that ataxin-10 is ubiquitinated, and is subject to proteasome-dependent degradation, which is delayed in the 2a mutant. We propose a model in which plk1 phosphorylation of ataxin-10 influences its degradation and cytokinesis |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
3.0
ATXN10
- 
- 