Relation Results

Summary

Name DNMT3B
Full Name DNA
Synonyms Dnmt3b, DNA methyltransferase HsaIIIB, DNA MTase HsaIIIB, M.HsaIIIB
Primary ID Q9UBC3
Links - -
Type protein
Relations 10
Function Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is ...
View More

Viewer

Type: Score: Layout: SPV 
0.7890.20.3290.40.330.3280.20.20.258DNMT3BDNMT1/DNMT3BBAG4DPP6miR-29bGSTM2BAG1BAG3IL32HOXB13

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations
Regulator
Mechanism
target
score ℹ
+ DNMT3Bform complex img/form-complex.png binding DNMT1/DNMT3B 0.789
Identifier Residue Sequence Organism Cell Line
SIGNOR-90845 Homo sapiens
pmid sentence
We show that the human de novo enzymes hdnmt3a and hdnmt3b form complexes with the major maintenance enzyme hdnmt1 /in vivo co-expression of hdnmt1 and hdnmt3a or hdnmt3b leads to methylation spreading in the genome, suggesting co-operation between de novo and maintenance enzymes during dna methylation
Publications: 1 Organism: Homo Sapiens
+ DNMT3Bup-regulates quantity by expression img/indirect-activation.png transcriptional regulation BAG4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254113 Homo sapiens HCT-116 Cell
pmid sentence
In contrast, an increase in BAG-1, BAG-3, and BAG-4 gene expression was observed in HCT116 cells overexpressing either DNMT1 (DNMT1+) or DNMT3B (DNMT3B+)
Publications: 1 Organism: Homo Sapiens
+ DNMT3Bdown-regulates quantity by repression img/direct_inhibition.png transcriptional regulation DPP6 0.329
Identifier Residue Sequence Organism Cell Line
SIGNOR-268963
pmid sentence
Dnmt3b was responsible for transcriptional silencing of Dpp6 gene as depletion of Dnmt3b resulted in increased mRNA and protein expression of Dpp6.
Identifier Residue Sequence Organism Cell Line
SIGNOR-268964 Mus musculus P-19 Cell
pmid sentence
In the absence of Dnmt3b, Dnmt3a was associated with Dpp6 gene promoter and regulated its expression and methylation in P19 cells.
Publications: 2 Organism: , Mus Musculus
+ miR-29bdown-regulates quantity by repression img/indirect_inhibition.png post transcriptional regulation DNMT3B 0.4
Identifier Residue Sequence Organism Cell Line
SIGNOR-264544 Mus musculus
pmid sentence
We also found that miR-199a expression and blockade (see below for details) potentiated and attenuated, respectively, the phosphorylation levels in neurons of S6 ribosomal protein, which signify the activation of mTOR signaling, indicating that miR-199a positively regulates mTOR signaling activity
Publications: 1 Organism: Mus Musculus
+ DNMT3Bdown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GSTM2 0.33
Identifier Residue Sequence Organism Cell Line
SIGNOR-271687
pmid sentence
Knockdown of Sp1 in normal lung cells reduced GST-M2 expression, and silencing of DNMT-3b increased GST-M2 expression in lung cancer cells.
Publications: 1
+ DNMT3Bup-regulates quantity by expression img/indirect-activation.png transcriptional regulation BAG1 0.328
Identifier Residue Sequence Organism Cell Line
SIGNOR-254109 Homo sapiens HCT-116 Cell
pmid sentence
DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation
Publications: 1 Organism: Homo Sapiens
+ DNMT3Bup-regulates quantity by expression img/indirect-activation.png transcriptional regulation BAG3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254111 Homo sapiens HCT-116 Cell
pmid sentence
In contrast, an increase in BAG-1, BAG-3, and BAG-4 gene expression was observed in HCT116 cells overexpressing either DNMT1 (DNMT1+) or DNMT3B (DNMT3B+)
Publications: 1 Organism: Homo Sapiens
+ DNMT3Bdown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation IL32 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254127 Homo sapiens A-549 Cell
pmid sentence
A virus or dsRNA in human PBMCs from healthy volunteers. We demonstrate that the NF-κB and CREB pathways play key roles in the activation of IL-32 production in response to influenza virus infection in A549 human lung epithelial cells.|Overexpression assays combined with RNA interference show that DNA methyltransferases DNMT1 and DNMT3b are critical for IL32 promoter methylation and gene silencing before viral infection.
Publications: 1 Organism: Homo Sapiens
+ DNMT3Bdown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation HOXB13 0.258
Identifier Residue Sequence Organism Cell Line
SIGNOR-254145 Homo sapiens Prostate Cancer Cell Line
pmid sentence
EZH2 recruited DNMT3b to HOXB13 promoter to form a repression complex.
Publications: 1 Organism: Homo Sapiens
a simple tooltip