Relation Results

Summary

Name EIF2B4
Full Name Translation initiation factor eIF-2B subunit delta
Synonyms eIF-2B GDP-GTP exchange factor subunit delta | EIF2BD
Primary ID Q9UI10
Links - -
Type protein
Relations 5
Function Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

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Type: Score: Layout: SPV 
0.20.7730.6970.7530.868GSK3BEIF2B4Ternary_GTP_eIF2_tRNA_complexEIF2S3EIF2S2EIF2S1

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Relations
Regulator
Mechanism
target
score ℹ
+ GSK3Bdown-regulates img/direct_inhibition.png binding EIF2B4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-175572 Homo sapiens
pmid sentence
Akt also promotes protein synthesis by phosphorylating and inactivating gsk3b, thus releasing the gsk3b-dependent inhibition of the eukariotic translation initiation factor 2b (eif2b).
Publications: 1 Organism: Homo Sapiens
+ EIF2B4up-regulates activity img/direct-activation.png guanine nucleotide exchange factor Ternary_GTP_eIF2_tRNA_complex 0.773
Identifier Residue Sequence Organism Cell Line
SIGNOR-269142 Homo sapiens
pmid sentence
EIF2B converts the protein synthesis initiation factor 2 (eIF2) from an inactive GDP-bound form to an active eIF2-GTP complex owing to its guanine nucleotide exchange factor (GEF) activity.
Publications: 1 Organism: Homo Sapiens
+ EIF2B4up-regulates activity img/direct-activation.png guanine nucleotide exchange factor EIF2S3 0.697
Identifier Residue Sequence Organism Cell Line
SIGNOR-269137 Homo sapiens
pmid sentence
EIF2B converts the protein synthesis initiation factor 2 (eIF2) from an inactive GDP-bound form to an active eIF2-GTP complex owing to its guanine nucleotide exchange factor (GEF) activity.
Publications: 1 Organism: Homo Sapiens
+ EIF2B4up-regulates activity img/direct-activation.png guanine nucleotide exchange factor EIF2S2 0.753
Identifier Residue Sequence Organism Cell Line
SIGNOR-269132 Homo sapiens
pmid sentence
EIF2B converts the protein synthesis initiation factor 2 (eIF2) from an inactive GDP-bound form to an active eIF2-GTP complex owing to its guanine nucleotide exchange factor (GEF) activity.
Publications: 1 Organism: Homo Sapiens
+ EIF2B4up-regulates activity img/direct-activation.png guanine nucleotide exchange factor EIF2S1 0.868
Identifier Residue Sequence Organism Cell Line
SIGNOR-269127 Homo sapiens
pmid sentence
EIF2B converts the protein synthesis initiation factor 2 (eIF2) from an inactive GDP-bound form to an active eIF2-GTP complex owing to its guanine nucleotide exchange factor (GEF) activity.
Publications: 1 Organism: Homo Sapiens
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