3.0
Summary
| Name |  PLXNA1
|
| Full Name | Plexin-A1 |
| Synonyms | Semaphorin receptor NOV | NOV, PLXN1 |
| Primary ID | Q9UIW2 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). |
binding