Summary

Name TMCO1
Full Name Calcium load-activated calcium channel
Synonyms CLAC channel, Transmembrane and coiled-coil domain-containing protein 1, Transmembrane and coiled-coil domains protein 4, Xenogeneic cross-immune protein PCIA3 | TMCC4
Primary ID Q9UM00
Links - -
Type protein
Relations 0
Function Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis (PubMed:27212239). In response to endoplasmic reticulum (ER) overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store (PubMed:27212239). Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis (PubMed:32820719). Together with SEC61 and TMCO1, forms the lipid-filled cavity at the center of the translocon where TMEM147 may insert hydrophobic segments of mutli-pass membrane proteins from the lumen into de central membrane cavity in a process gated by SEC61, and TMCO1 may insert hydrophobic segments of nascent chains from the cytosol into the cavity (PubMed:32820719).

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