Summary

Name TNFSF13B
Full Name Tumor necrosis factor ligand superfamily member 13B
Synonyms B lymphocyte stimulator, BLyS, B-cell-activating factor, BAFF, Dendritic cell-derived TNF-like molecule, TNF- and APOL-related leukocyte expressed ligand 1, TALL-1 | BAFF, BLYS, TALL1, TNFSF20, ZTNF4
Primary ID Q9Y275
Links - -
Type protein
Relations 3
Pathways NF-KB Non Canonical
Function Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding TNFRSF13C 0.779
Publications: 2 Organism: Homo Sapiens
Pathways:NF-KB Non Canonical
+ up-regulates img/direct-activation.png binding TNFRSF13B 0.775
Publications: 1 Organism: Homo Sapiens