Summary

Name CIAO2B
Full Name Cytosolic iron-sulfur assembly component 2B
Synonyms MSS19-interacting protein of 18 kDa, Mitotic spindle-associated MMXD complex subunit MIP18, Protein FAM96B | CIAB, FAM96B, MIP18
Primary ID Q9Y3D0
Links - -
Type protein
Relations 1
Function Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:22678361, PubMed:22678362, PubMed:23891004, PubMed:29848660). As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins (PubMed:23891004, PubMed:29848660). As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD (PubMed:20797633). Together with MMS19, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis (PubMed:29848660).

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Relations

Regulator Mechanism target score ℹ
+ CIAO2Bform complex img/form-complex.png binding CIAO2B cytosolic iron-sulfur protein assembly complex 0.2
Publications: 1 Organism: Homo Sapiens