| + |
GPCR | up-regulates activity 
binding
|
GNAI1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255006 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31160049 |
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Neurotransmitters release |
| + |
GPCR | up-regulates
|
GNAI1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255009 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23994464 |
Activation of those receptors triggers the dissociation of the GPCR-specific Gα subunit from the shared Gβγ dimer and concomitant activation of various signal transduction pathways by both G-protein fragments |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Neurotransmitters release |
| + |
GPCR | up-regulates activity
binding
|
GNB/GNG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255007 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23994464 |
Instead, our current understanding is that the majority of GPCR signal transduction in neutrophils occurs through the G gamma/beta subunit. G-protein-coupled receptors in neutrophils primarily signal through the Gβγ heterodimer, activating two parallel pathways through PLCβ2/3 and PI3Kγ. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
GPCR