Relation Results

Summary

Name G0/G1_transition
Primary ID SIGNOR-PH219
Type phenotype
Description He mitotic cell cycle phase transition whose occurrence commits the cell from the G0 quiescent state to the G1 phase (GO:0045023).
Relations 3

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Type: Score: Layout: SPV 
0.70.70.7CyclinD/CDK4G0/G1_transitionCyclinD1/CDK6CyclinC/CDK3

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Relations
Regulator
Mechanism
target
score ℹ
+ CyclinD/CDK4up-regulates img/indirect-activation.png G0/G1_transition 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-273193
pmid sentence
Transition through this point requires cdk6/4-cyclin D, since inhibition with TAT-p16INK4A during the first 3 to 5 h prevents cell cycle entry and maintains both naive and memory T cells in G0.
Publications: 1
+ CyclinD1/CDK6up-regulates img/indirect-activation.png G0/G1_transition 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-273192
pmid sentence
Transition through this point requires cdk6/4-cyclin D, since inhibition with TAT-p16INK4A during the first 3 to 5 h prevents cell cycle entry and maintains both naive and memory T cells in G0.
Publications: 1
+ CyclinC/CDK3up-regulates img/indirect-activation.png G0/G1_transition 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-273190
pmid sentence
Among them, CDK3 is critically important because it triggers the transitions of G0 to G1 and G1 to S phase through binding to cyclin C and cyclin E1, respectively.
Publications: 1
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