3.0
FAP: SHH
Pathway ID: SIGNOR-FapSHH
Description: Sonic Hedgehog signaling pathway regulates developmental processes by modulating the expression of downstream target genes: Sonic Hedgehog protein leads to the activation of Smoothened (SMO) - a seven-transmembrane protein - through the inhibition of Patched Receptor (Ptch1). Then, SMO activates the expression of GATA2 that is an important anti-adipogenic transcription factor, which binds and inhibits the peroxisome proliferator-activated receptor γ (PPARγ) promoter.
Curated by: Federica Ferrentino
Description: Sonic Hedgehog signaling pathway regulates developmental processes by modulating the expression of downstream target genes: Sonic Hedgehog protein leads to the activation of Smoothened (SMO) - a seven-transmembrane protein - through the inhibition of Patched Receptor (Ptch1). Then, SMO activates the expression of GATA2 that is an important anti-adipogenic transcription factor, which binds and inhibits the peroxisome proliferator-activated receptor γ (PPARγ) promoter.
Curated by: Federica Ferrentino
