Summary

Name PPARG
Full Name Peroxisome proliferator-activated receptor gamma
Synonyms PPAR-gamma, Nuclear receptor subfamily 1 group C member 3 | NR1C3
Primary ID P37231
Links - -
Type protein
Relations 119
Pathways Adipogenesis, Circadian clock, FAP: In vitro induction of adipogenesis, FAP: Adipogenic transcriptional cascade, FAP: Glucocorticoids, FAP: IBMX/rosiglitazone, FAP: IL4/IL13 induction, FAP: Insulin-mediated adipogenesis, FAP: Notch, FAP: SHH, FAP: SIRT1, FAP: TGF beta, FAP: Wnt, FAP: GCR-cAMP crosstalk, FAP: INSR, FAP: IL15, FAP: miRNA and adipogensis, Leptin Signaling, Macrophage polarization, Macrophage: IL4, Macrophage: Polarization and myogenesis, MTOR Signaling, Prostate Cancer, PPARgamma in cancer, Rett syndrome, Thyroid cancer
Inhibitors 2,5-dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide
Function Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation PPARG 0.548
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PPARG 0.473
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PPARG 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Leptin Signaling, MTOR Signaling, Rett syndrome, Thyroid cancer
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PPARG 0.413
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png phosphorylation PPARG 0.348
Publications: 2 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png PPARG 0.41
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PPARG 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png NfKb-p65/p50 0.596
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG 0.578
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates img/direct-activation.png PPARG 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:PPARgamma in cancer
+ down-regulates img/direct_inhibition.png phosphorylation, relocalization PPARG 0.473
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png transcriptional regulation PPARG 0.359
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PPARG 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:PPARgamma in cancer
+ up-regulates img/indirect-activation.png PPARG 0.257
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PPARGC1A 0.898
Publications: 1 Organism: Mus Musculus
Pathways:Circadian clock, MTOR Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG 0.48
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png chemical activation PPARG 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png STAT3 0.39
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling, Macrophage polarization
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG 0.288
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PPARG 0.252
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png PTEN 0.476
Publications: 1 Organism: Homo Sapiens
Pathways:MTOR Signaling, Prostate Cancer, Thyroid cancer
+ down-regulates img/indirect_inhibition.png PPARG 0.56
Publications: 1 Organism: Homo Sapiens
Pathways:PPARgamma in cancer, Thyroid cancer
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation PPARG 0.287
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL10 0.383
Publications: 1
Pathways:Macrophage polarization
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG 0.425
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity img/direct_inhibition.png post transcriptional regulation PPARG 0.4
Publications: 1 Organism: Rattus Norvegicus
Pathways:Rett syndrome
+ down-regulates img/indirect_inhibition.png transcriptional regulation PPARG 0.481
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPARG 0.647
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation PPARG 0.719
Publications: 2 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG 0.8
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png relocalization HDAC1 0.596
Publications: 1 Organism: Homo Sapiens
Pathways:Prostate Cancer
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation PPARG 0.252
Publications: 1 Organism: Homo Sapiens
Tissue: Liver
+ up-regulates img/indirect-activation.png PPARG 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation PPARG 0.381
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, FAP: Insulin-mediated adipogenesis
+ down-regulates activity img/direct_inhibition.png relocalization PPARG 0.413
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png relocalization PPARG 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png PPARG 0.423
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG 0.511
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis, FAP: Insulin-mediated adipogenesis, Leptin Signaling, MTOR Signaling
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation PPARG 0.733
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PPARG 0.359
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation NR1D1 0.282
Publications: 1 Organism: Mus Musculus
Pathways:Circadian clock
+ up-regulates img/direct-activation.png binding PPARG 0.463
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png PPARG 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG 0.533
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation ARNTL 0.411
Publications: 1 Organism: Mus Musculus
Pathways:Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG 0.291
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity img/indirect_inhibition.png post transcriptional regulation PPARG 0.4
Publications: 1 Organism: Mus Musculus
Pathways:Rett syndrome
+ up-regulates activity img/direct-activation.png chemical activation PPARG 0.8
Publications: 3 Organism: In Vitro, Homo Sapiens, Chlorocebus Aethiops
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PPARG 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/indirect_inhibition.png PPARG 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG 0.403
Publications: 3 Organism: Mus Musculus
Pathways:Adipogenesis, Circadian clock
+ up-regulates activity img/indirect-activation.png JUN 0.569
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png transcriptional regulation PPARG 0.434
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation PPARG 0.605
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling
+ up-regulates img/direct-activation.png binding PPARG 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding PPARG 0.319
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding PPARG 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition PPARG 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PPARG 0.481
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation PPARG 0.689
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FABP4 0.675
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
+ up-regulates img/indirect-activation.png transcriptional regulation PPARG 0.48
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png transcriptional regulation CEBPA 0.642
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG 0.331
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ down-regulates activity img/direct_inhibition.png binding PPARG 0.56
Publications: 1 Organism: Mus Musculus
Pathways:PPARgamma in cancer, Thyroid cancer
+ up-regulates img/indirect-activation.png Adipogenesis 0.7
Publications: 2 Organism: Mus Musculus
Tissue: Mammary Epithelial Cell
Pathways:Adipogenesis, Circadian clock, FAP: Insulin-mediated adipogenesis, Leptin Signaling, MTOR Signaling, PPARgamma in cancer
+ down-regulates quantity img/direct_inhibition.png post transcriptional regulation PPARG 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG 0.289
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png PPARG 0.283
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png phosphorylation PPARG 0.2
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis, Leptin Signaling, MTOR Signaling, Rett syndrome, Thyroid cancer
+ up-regulates img/direct-activation.png binding PPARG 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Rett syndrome, Thyroid cancer
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ABCG2 0.41
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/indirect-activation.png transcriptional regulation PPARG 0.403
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis, Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG 0.453
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CXCR2 0.269
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG 0.266
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GLS 0.25
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CTNNB1 0.56
Publications: 1 Organism: Homo Sapiens
Pathways:PPARgamma in cancer, Thyroid cancer
+ up-regulates activity img/direct-activation.png chemical activation PPARG 0.8
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png binding ACADM 0.358
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPARG 0.725
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPARG 0.487
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation PPARG 0.693
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPARG 0.754
Publications: 1 Organism: Homo Sapiens
Pathways:Prostate Cancer
+ up-regulates img/indirect-activation.png transcriptional regulation PPARG 0.605
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ down-regulates activity img/indirect_inhibition.png PPARG 0.533
Publications: 1 Organism: Mus Musculus
Pathways:Macrophage polarization
+ up-regulates activity img/direct-activation.png chemical activation PPARG 0.8
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PPARG 0.325
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png PPARG 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png M2_polarization 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Macrophage polarization
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CPT1B 0.4
Publications: 1 Organism: Mus Musculus
+ down-regulates img/indirect_inhibition.png PPARG 0.279
Publications: 1
Tissue: Mammary Epithelial Cell
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG 0.35
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
Pathways:Rett syndrome
+ down-regulates img/indirect_inhibition.png PPARG 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation FABP4 0.675
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/indirect-activation.png PPARG 0.468
Publications: 1 Organism: Mus Musculus
Pathways:Circadian clock, MTOR Signaling
+ up-regulates activity img/direct-activation.png chemical activation PPARG 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PPARG 0.434
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PPARG 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png PPARG 0.381
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, FAP: Insulin-mediated adipogenesis
+ up-regulates activity img/direct-activation.png chemical activation PPARG 0.8
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/indirect_inhibition.png transcriptional regulation PPARG 0.427
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PPARG 0.2
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation UCP1 0.556
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PPARG 0.274
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png chemical activation PPARG 0.8
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png PPARG 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PPARG 0.566
Publications: 1 Organism: Rattus Norvegicus
Pathways:Adipogenesis, FAP: Insulin-mediated adipogenesis, Leptin Signaling