Pathway ID: SIGNOR-Myostatin

Description: Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine that inhibits myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family. Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade , which includes the activation of transcription factors in the SMAD family

Curated by: gcesareni

complexity level

level 1 seed interactions
level 2 connect
level 3 first neighbors
level 4 all
level 5 PPI

19 Seed Entities

Name Primary ID
ACVR1B P36896
MYOD1 P15172
IGF1 P05019
IGF1R P08069
SMAD3 P84022
MSTN O14793
SMAD2 Q15796
FBXO32 Q969P5
SMAD4 Q13485
Skeletal Muscle Differentiation SIGNOR-PH1
PIK3CA P42336
INHBA P08476
FST P19883
Muscle atrophy SIGNOR-PH40
PtsIns(3,4,5)P3 CID:24755492
FOXO1 Q12778
ACVR2B Q13705
PDPK1 O15530