| + |
FOXO | up-regulates 
|
Muscle_atrophy |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252932 |
|
|
Mus musculus |
Skeletal Muscle |
| pmid |
sentence |
| 15109499 |
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FOXO3 | up-regulates
|
Muscle_atrophy |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241949 |
|
|
Mus musculus |
Skeletal Muscle |
| pmid |
sentence |
| 15109499 |
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
Caspase 3 complex | up-regulates
|
Muscle_atrophy |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256475 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25787076 |
The UPS by itself degrades actomyosin and myofibrillar proteins slowly, but when caspase-3 is activated, it cleaves actomyosin and the myofibrillar proteins to provide substrates for degradation in the UPS . Caspase-3 also can cleave specific subunits of the 19 S proteasome particle, which stimulates the proteolytic activity of the 26S proteasome[...] These results indicate that caspase-3 participates in the muscle proteolysis that is present in tumor-bearing mice |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TRIM63 | up-regulates activity
|
Muscle_atrophy |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254993 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25549588 |
Muscle-specific ubiq- uitin ligases, muscle-specific RING-finger 1 (MURF1; also known as TRIM63)12 and atrogin 1 (also known as MAFBX), are markedly induced in almost all types of atrophy. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FBXO32 | up-regulates activity
|
Muscle_atrophy |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254994 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25549588 |
Muscle-specific ubiq- uitin ligases, muscle-specific RING-finger 1 (MURF1; also known as TRIM63)12 and atrogin 1 (also known as MAFBX)8, are markedly induced in almost all types of atrophy. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FBXO32 | up-regulates
|
Muscle_atrophy |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255343 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20871233 |
Atrogin-1, but not MuRF-1, was induced at both the gene and protein level as ApcMin/+ mice aged from 3 to 6 months of age, going from a pre-cachectic to a cachectic state. Atrogin-1 mRNA and protein levels were also elevated in ApcMin/+ mice when we over-expressed IL-6 in the circulation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252072 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25096180 |
Muscle RING finger 1 (MuRF1) and muscle atrophy F-box (MAFbx)/atrogin-1 were identified more than 10 years ago as two muscle-specific E3 ubiquitin ligases that are increased transcriptionally in skeletal muscle under atrophy-inducing conditions, making them excellent markers of muscle atrophy |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255344 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11717410 |
Atrogin-1 is one of the few examples of an F-box protein or Ub-protein ligase (E3) expressed in a tissue-specific manner and appears to be a critical component in the enhanced proteolysis leading to muscle atrophy in diverse diseases |
|
| Publications: |
3 |
Organism: |
Mus Musculus |
| Tissue: |
Skeletal Muscle |
| + |
CASP3 | up-regulates
|
Muscle_atrophy |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255336 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25787076 |
The UPS by itself degrades actomyosin and myofibrillar proteins slowly, but when caspase-3 is activated, it cleaves actomyosin and the myofibrillar proteins to provide substrates for degradation in the UPS . Caspase-3 also can cleave specific subunits of the 19 S proteasome particle, which stimulates the proteolytic activity of the 26S proteasome[...] These results indicate that caspase-3 participates in the muscle proteolysis that is present in tumor-bearing mice |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FBXO30 | up-regulates
|
Muscle_atrophy |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256489 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24076600 |
gene (Fbxo30) that encodes a ubiquitin ligase required for muscle loss, which we named muscle ubiquitin ligase of the SCF complex in atrophy-1 (MUSA1) |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Muscle |
3.0
Muscle_atrophy