3.0
T-Lymphocyte: IFN gamma
Pathway ID: SIGNOR-TLymphIFNG
Description: CD4+ helper T cells (named TH cells) are key players for adaptive immunity. Upon contact with antigens and depending on the cytokine microenvironments, they are able to differentiate into three types of cells, named Th1, Th2 and T-reg. Th1 cells produce interferon gamma, Th2 cells produce IL-4 and IL-13, and T-reg produce IL-10. The master genes for these three cellular types ar T-BET for Th1, GATA3 for Th2 and finally FOXP3 for T-reg. Interferon gamma binds its receptor, which in turn activates JAK/STAT pathway using STAT1 as transcription factors. At transcriptional level, STAT1 is able to upregulate T-BET expression, which in turn is an IFN-gamma activator and an inhibitor of GATA3. IFN gamma transcription is promoted by TBET and downregulated by Prospero homeobox protein 1.
Curated by: Alessandro Palma
Description: CD4+ helper T cells (named TH cells) are key players for adaptive immunity. Upon contact with antigens and depending on the cytokine microenvironments, they are able to differentiate into three types of cells, named Th1, Th2 and T-reg. Th1 cells produce interferon gamma, Th2 cells produce IL-4 and IL-13, and T-reg produce IL-10. The master genes for these three cellular types ar T-BET for Th1, GATA3 for Th2 and finally FOXP3 for T-reg. Interferon gamma binds its receptor, which in turn activates JAK/STAT pathway using STAT1 as transcription factors. At transcriptional level, STAT1 is able to upregulate T-BET expression, which in turn is an IFN-gamma activator and an inhibitor of GATA3. IFN gamma transcription is promoted by TBET and downregulated by Prospero homeobox protein 1.
Curated by: Alessandro Palma
