Summary

Name STAT1
Full Name Signal transducer and activator of transcription 1-alpha/beta
Synonyms Transcription factor ISGF-3 components p91/p84
Primary ID P42224
Links - -
Type protein
Relations 68
Pathways EBV infection, Macrophage: IFN gamma, Macrophage: Polarization and myogenesis, P38 Signaling, SARS-CoV CYTOKINE STORM, Satellite: IFN gamma, T-Lymphocyte: IFN gamma
Function Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png methylation STAT1 0.27
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT1 0.407
Publications: 1
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAT1 0.733
Publications: 2 Organism: Homo Sapiens
Pathways:EGFR Signaling
+ up-regulates img/direct-activation.png phosphorylation STAT1 0.567
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT1 0.479
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation STAT1 0.375
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT1 0.302
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation STAT1 0.708
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation STAT1 0.414
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT1 0.768
Publications: 1 Organism: In Vitro
Pathways:EBV infection
+ up-regulates activity img/direct-activation.png phosphorylation STAT1 0.784
Publications: 3 Organism: Homo Sapiens, In Vitro
Pathways:EBV infection, SARS-CoV CYTOKINE STORM
+ down-regulates activity img/direct_inhibition.png dephosphorylation STAT1 0.723
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT1 0.656
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation STAT1 0.723
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation STAT1 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation STAT1 0.465
Publications: 1 Organism: Mus Musculus
Pathways:EGFR Signaling
+ up-regulates activity img/direct-activation.png phosphorylation STAT1 0.712
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation STAT1 0.801
Publications: 3 Organism: Homo Sapiens,
Tissue: Skeletal Muscle
Pathways:EGFR Signaling, EBV infection
+ up-regulates activity img/direct-activation.png phosphorylation STAT1 0.582
Publications: 1 Organism: Homo Sapiens
Tissue: Lung
Pathways:EGFR Signaling
+ up-regulates activity img/direct-activation.png phosphorylation STAT1 0.355
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png TBX21 0.512
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation STAT1 0.59
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, EBV infection, SARS-CoV CYTOKINE STORM
+ up-regulates activity img/direct-activation.png binding IRF2 0.569
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL12A 0.526
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM
+ form complex img/form-complex.png binding STAT1/STAT3 0.59
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation STAT1 0.626
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding ISGF3 complex 0.67
Publications: 1 Organism: In Vitro
Pathways:SARS-CoV CYTOKINE STORM
+ down-regulates img/direct_inhibition.png binding STAT1 0.54
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IRF7 0.503
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection, SARS-CoV CYTOKINE STORM
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation S100A10 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT1 0.666
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection, SARS-CoV CYTOKINE STORM
+ down-regulates img/direct_inhibition.png binding STAT1 0.784
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOCS1 0.626
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png STAT1 0.482
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/indirect-activation.png transcriptional regulation CIITA 0.524
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates img/indirect-activation.png M1_polarization 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation STAT1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Esophageal Cancer Cell Line
+ down-regulates img/indirect_inhibition.png Proliferation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, EBV infection, P38 Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TAP1 0.278
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MMP13 0.297
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding NfKb-p65/p50 0.464
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection, SARS-CoV CYTOKINE STORM
+ up-regulates img/direct-activation.png transcriptional regulation CIITA 0.524
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates activity img/direct-activation.png binding STAT1 0.529
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT1 0.727
Publications: 2 Organism: Homo Sapiens
Pathways:EGFR Signaling
+ down-regulates img/direct_inhibition.png binding RELA 0.537
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TLR3 0.465
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KRT17 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding STAT1 0.463
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SOCS3 0.667
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation NOS2 0.446
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation STAT1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection
+ down-regulates activity img/indirect_inhibition.png relocalization STAT1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM
+ up-regulates activity img/direct-activation.png binding STAT1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, EBV infection, P38 Signaling, SARS-CoV CYTOKINE STORM
+ down-regulates activity img/indirect_inhibition.png STAT1 0.2
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation STAT1 0.784
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection, SARS-CoV CYTOKINE STORM
+ up-regulates img/indirect-activation.png STAT1 0.278
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MUC4 0.404
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CIITA 0.524
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png STAT1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL12B 0.441
Publications: 1 Organism: Homo Sapiens