3.0
T-Lymphocyte: ATP
Pathway ID: SIGNOR-TLymphATP
Description: Upon myofibers degeneration cytoplasmic content is released in the extracelluar space. ATP is one of the most abundant molecules in the cytoplasm and could act as a DAMP molecule (Damage Associated Molecular Pattern) for the activation of immune system cells. ATP binds to many members of Purinergic 2 X (P2X) receptors superfamily contributing to the control of cell metabolism and function. ATP and P2X7 receptors result to be negative modulators of Treg phenotype through the activation of ERK kinase.
Curated by: Marco Rosina
Description: Upon myofibers degeneration cytoplasmic content is released in the extracelluar space. ATP is one of the most abundant molecules in the cytoplasm and could act as a DAMP molecule (Damage Associated Molecular Pattern) for the activation of immune system cells. ATP binds to many members of Purinergic 2 X (P2X) receptors superfamily contributing to the control of cell metabolism and function. ATP and P2X7 receptors result to be negative modulators of Treg phenotype through the activation of ERK kinase.
Curated by: Marco Rosina
6 Seed Entities
Organism: 
|
Name | Primary ID |
|---|---|
| Adenosine triphosphate | CID:5957 |
| ERK1/2 | SIGNOR-PF1 |
| FOXP3 | Q9BZS1 |
| P2RX7 | Q99572 |
| PLD2 | O14939 |
| T-reg_differentiation | SIGNOR-PH91 |