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Modifications Tables

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Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation SMAD2
Publications: 6 Organism: Homo Sapiens
Tissue: Lung, Breast, Lung
Pathways:T-Lymphocyte: IL6
+ up-regulates img/direct-activation.png phosphorylation CDKN1B
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HDAC6
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ESR1
Publications: 3 Organism: Homo Sapiens
Pathways:Luminal Breast Cancer
+ up-regulates activity img/direct-activation.png phosphorylation PPARG
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, MTOR Signaling, Thyroid cancer
+ down-regulates activity img/direct_inhibition.png phosphorylation SOS1
Publications: 4 Organism: Chlorocebus Aethiops, Homo Sapiens
Tissue: Lung, Breast
Pathways:Adipogenesis, Acute Myeloid Leukemia, Colorectal Carcinoma, EGFR, Glioblastoma Multiforme, IL6 , Insulin Receptor, Inhibition of Apoptosis, Luminal Breast Cancer, Malignant Melanoma, Noonan syndrome, Rhabdomyosarcoma, Thyroid cancer, T cell activation
+ up-regulates img/direct-activation.png phosphorylation SREBF1
Publications: 1 Organism: Homo Sapiens
Pathways:Insulin Receptor, MTOR Signaling
+ down-regulates img/direct_inhibition.png phosphorylation SOS1
Publications: 2 Organism: Homo Sapiens
Pathways:Adipogenesis, Acute Myeloid Leukemia, Colorectal Carcinoma, EGFR, Glioblastoma Multiforme, IL6 , Insulin Receptor, Inhibition of Apoptosis, Luminal Breast Cancer, Malignant Melanoma, Noonan syndrome, Rhabdomyosarcoma, Thyroid cancer, T cell activation
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1A
Publications: 2 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ down-regulates img/direct_inhibition.png phosphorylation CIC
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MITF
Publications: 1 Organism: Homo Sapiens
Pathways:Malignant Melanoma
+ up-regulates activity img/direct-activation.png phosphorylation RPS6K
Publications: 6 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KA1
Publications: 6 Organism: Chlorocebus Aethiops
Pathways:AMPK Signaling, Inhibition of Apoptosis, MTOR Signaling
+ up-regulates img/direct-activation.png phosphorylation SPHK1
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6KA3
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EP300
Publications: 3 Organism: Homo Sapiens
Pathways:T-Lymphocyte: IL6
+ up-regulates img/direct-activation.png phosphorylation RUNX1
Publications: 4 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ up-regulates img/direct-activation.png phosphorylation RXRA
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GPHN
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation RAF1
Publications: 2 Organism: Homo Sapiens
Pathways:Adipogenesis, Insulin Receptor, Noonan syndrome
+ up-regulates img/direct-activation.png phosphorylation H3F3A
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RAF1
Publications: 2 Organism: Homo Sapiens
Pathways:Adipogenesis, Insulin Receptor, Noonan syndrome
+ up-regulates img/direct-activation.png phosphorylation ELK1
Publications: 6 Organism: Homo Sapiens
Pathways:EGFR, Glioblastoma Multiforme, IL6 , Noonan syndrome
+ up-regulates img/direct-activation.png phosphorylation HNRNPK
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6KA5
Publications: 2 Organism: Homo Sapiens
Pathways:Adipogenesis, Malignant Melanoma
+ up-regulates img/direct-activation.png phosphorylation CSNK2A1
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PARP1
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation AP1
Publications: 4 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates img/direct-activation.png phosphorylation FOS
Publications: 4 Organism: Homo Sapiens
Pathways:EGFR, T cell activation
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KA5
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Malignant Melanoma
+ down-regulates img/direct_inhibition.png phosphorylation CASP8
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ down-regulates activity img/direct_inhibition.png phosphorylation STK11
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling
+ down-regulates img/direct_inhibition.png phosphorylation GAB1
Publications: 4 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, EGFR, Noonan syndrome, Rhabdomyosarcoma
+ down-regulates img/direct_inhibition.png phosphorylation AR
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation JAK2
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:Eosinophil: IL5, Mast cell: SCF
+ down-regulates img/direct_inhibition.png phosphorylation MYB
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TSC2
Publications: 2 Organism: Mus Musculus, Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation MYC
Publications: 1 Organism: Rattus Norvegicus
Pathways:Acute Myeloid Leukemia, Colorectal Carcinoma, EGFR, Rhabdomyosarcoma, Thyroid cancer
+ down-regulates img/direct_inhibition.png phosphorylation TSC2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation BCL2
Publications: 3 Organism: Chlorocebus Aethiops, Homo Sapiens
Pathways:Acute Myeloid Leukemia, Colorectal Carcinoma, Inhibition of Apoptosis, Malignant Melanoma
+ down-regulates img/direct_inhibition.png phosphorylation FGFR1
Publications: 1 Organism: Homo Sapiens
Pathways:Luminal Breast Cancer
+ up-regulates img/direct-activation.png phosphorylation CDK2
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ up-regulates activity img/direct-activation.png phosphorylation MAPK3
Publications: 1 Organism: Homo Sapiens
Tissue: Heart
+ up-regulates activity img/direct-activation.png phosphorylation CEBPB
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ up-regulates img/direct-activation.png phosphorylation SMAD4
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma
+ down-regulates activity img/direct_inhibition.png phosphorylation MAP2K1
Publications: 2 Organism: Chlorocebus Aethiops, Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MKNK1
Publications: 3 Organism: Homo Sapiens, In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation BRAF
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Colorectal Carcinoma, EGFR, Glioblastoma Multiforme, IL6 , Inhibition of Apoptosis, Luminal Breast Cancer, Malignant Melanoma, Noonan syndrome, Rhabdomyosarcoma, Thyroid cancer, T cell activation
+ up-regulates img/direct-activation.png phosphorylation BCL2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Colorectal Carcinoma, Inhibition of Apoptosis, Malignant Melanoma
+ down-regulates img/direct_inhibition.png phosphorylation EGFR
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, Glioblastoma Multiforme, Noonan syndrome
+ up-regulates img/direct-activation.png phosphorylation ADAM17
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TSC1
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown ERK1/2
Publications: 1 Organism: Homo Sapiens
Pathways:Eosinophil: IL5
+ up-regulates img/indirect-activation.png unknown Proliferation
Publications: 3 Organism: Homo Sapiens, Mus Musculus
Pathways:Acute Myeloid Leukemia, Colorectal Carcinoma, EGFR, Eosinophil: IL5, FAP: PDGFR alpha, Glioblastoma Multiforme, IL6 , Luminal Breast Cancer, Mast cell: SCF, Malignant Melanoma, Rhabdomyosarcoma, Satellite: CCR2, Thyroid cancer
+ up-regulates img/indirect-activation.png unknown Differentiation
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Eosinophil: IL5
+ up-regulates img/indirect-activation.png unknown ERK1/2
Publications: 1 Organism: Homo Sapiens
Pathways:Eosinophil: CCL11
+ up-regulates img/indirect-activation.png unknown Inflammation
Publications: 1 Organism: Homo Sapiens
Pathways:Eosinophil: CCL11
+ up-regulates img/indirect-activation.png unknown Fibrosis
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation JUN
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, Glioblastoma Multiforme, Insulin Receptor, Luminal Breast Cancer
+ down-regulates img/indirect_inhibition.png unknown T-reg differentiation
Publications: 2 Organism: Homo Sapiens
Pathways:T-Lymphocyte: ATP
+ up-regulates img/indirect-activation.png unknown ERK1/2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Mast cell: SCF, Malignant Melanoma
+ up-regulates img/indirect-activation.png unknown Survival
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, Glioblastoma Multiforme, Inhibition of Apoptosis, Luminal Breast Cancer, Mast cell: SCF, Malignant Melanoma, Rhabdomyosarcoma, Thyroid cancer
+ up-regulates img/indirect-activation.png unknown ERK1/2
Publications: 1 Organism: Homo Sapiens
Pathways:T-Lymphocyte: ATP
+ up-regulates img/indirect-activation.png phosphorylation ERK1/2
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 , T-Lymphocyte: IL6
+ up-regulates img/direct-activation.png phosphorylation ERK1/2
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Colorectal Carcinoma, Thyroid cancer
+ up-regulates activity img/indirect-activation.png phosphorylation ERK1/2
Publications: 1 Organism: Mus Musculus
Pathways:Satellite: CCR2
+ up-regulates activity img/indirect-activation.png phosphorylation ERK1/2
Publications: 1 Organism: Mus Musculus
Pathways:Satellite: CCR2
+ up-regulates activity img/indirect-activation.png phosphorylation ERK1/2
Publications: 1 Organism: Mus Musculus
Pathways:Satellite: CCR2
+ down-regulates activity img/direct_inhibition.png phosphorylation MEK1/2
Publications: 2 Organism: Chlorocebus Aethiops, Homo Sapiens
Pathways:Adipogenesis, Acute Myeloid Leukemia, Colorectal Carcinoma, EGFR, Glioblastoma Multiforme, IL6 , Insulin Receptor, Inhibition of Apoptosis, Luminal Breast Cancer, Malignant Melanoma, Noonan syndrome, Rhabdomyosarcoma, Thyroid cancer, T cell activation, Tol like receptors
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD
Publications: 1 Organism: In Vitro
Pathways:Inhibition of Apoptosis, Mast cell: SCF, Malignant Melanoma
+ up-regulates activity img/indirect-activation.png unknown ERK1/2
Publications: 1 Organism: Mus Musculus
Pathways:EGFR, IL6 , Noonan syndrome, Thyroid cancer
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SOX2
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CEBPA
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis, Acute Myeloid Leukemia
+ up-regulates activity img/direct-activation.png phosphorylation E2F1
Publications: 1 Organism: Homo Sapiens
Pathways:Luminal Breast Cancer, Malignant Melanoma
+ up-regulates img/indirect-activation.png transcriptional regulation CEBPA
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis, Acute Myeloid Leukemia
+ up-regulates activity img/direct-activation.png phosphorylation SP1
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD2
Publications: 1 Organism: Homo Sapiens
Tissue: Lung, Breast
Pathways:T-Lymphocyte: IL6
+ up-regulates img/direct-activation.png phosphorylation LRP6
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown ERK1/2
Publications: 1 Organism: Homo Sapiens
Pathways:FAP: PDGFR alpha, Rhabdomyosarcoma
+ up-regulates activity img/direct-activation.png phosphorylation ELK1
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, Glioblastoma Multiforme, IL6 , Noonan syndrome
+ up-regulates activity img/direct-activation.png phosphorylation ERK1/2
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation ERK1/2
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Acute Myeloid Leukemia, Colorectal Carcinoma, EGFR, Glioblastoma Multiforme, IL6 , Insulin Receptor, Inhibition of Apoptosis, Luminal Breast Cancer, Malignant Melanoma, Noonan syndrome, Rhabdomyosarcoma, Thyroid cancer, T cell activation, Tol like receptors
+ up-regulates img/indirect-activation.png transcriptional regulation SOX9
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ERK1/2
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid cancer
+ up-regulates img/direct-activation.png phosphorylation ERK1/2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown ERK1/2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation JUN
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR, Glioblastoma Multiforme, Insulin Receptor, Luminal Breast Cancer
+ down-regulates img/indirect_inhibition.png unknown MAPK14
Publications: 1 Organism: Homo Sapiens
Pathways:Tol like receptors
+ up-regulates quantity by expression img/direct-activation.png phosphorylation PPARG
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis, MTOR Signaling, Thyroid cancer