| + |
GTP | form complex 
binding
|
Ternary_GTP_eIF2_tRNA_complex |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269118 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32955564 |
In eukaryotes, translation initiation generally occurs by a cap-dependent scanning mechanism, wherein the small (40S) subunit of the ribosome recruits methionyl initiator tRNA (Met-tRNAi) in a ternary complex (TC) with GTP-bound eukaryotic initiation factor 2 (eIF2), in a reaction stimulated by factors eIF1, eIF1A and eIF3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Initiation of Translation |
| + |
GTP | up-regulates 
chemical activation
|
GNAI1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-88238 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12040175 |
Agonist binding triggers a conformational change in the receptor, which catalyses the dissociation of gdp from the alfa subunit followed by gtp-binding to galfa and the dissociation of galfa from gbetagamma subunits1. The alfa subunits of g proteins are divided into four subfamilies: galfas, galfai, galfaq and galfa12, and a single gpcr can couple to either one or more families of galfa proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GTP | up-regulates
chemical activation
|
GNAS |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253071 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17095603 |
Galfa subunits cycle between inactive (gdp-bound) and active (gtp-bound) states, and the lifetime of the active state is limited by gtp hydrolysis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GTP | form complex
binding
|
EEF1A:GTP:aa-tRNA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270812 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8722040 |
The mechanism of elongation factor Tu (EF-Tu) catalyzed aminoacyl-tRNA (aa-tRNA) binding to the A site of the ribosome was studied. Two types of complexes of EF-Tu with GTP and aa-tRNA, EF-Tu.GTP-aa-tRNA (ternary) and (EF-Tu.GTP)2.aa-tRNA (quinternary), can be formed in vitro depending on the conditions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Translation elongation and termination |
| + |
GTP | form complex
binding
|
Translation release factor ERF1-ERF3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275394 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29735640 |
Termination of mRNA translation occurs when a stop codon enters the A site of the ribosome, and in eukaryotes is mediated by release factors eRF1 and eRF3, which form a ternary eRF1/eRF3-guanosine triphosphate (GTP) complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Translation elongation and termination |
| + |
GTP | up-regulates
chemical activation
|
GNAS |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150552 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17095603 |
Galfa subunits cycle between inactive (gdp-bound) and active (gtp-bound) states, and the lifetime of the active state is limited by gtp hydrolysis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
GTP