| + |
GSPT1 | form complex 
binding
|
Translation release factor ERF1-ERF3 |
0.973 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270814 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29735640 |
Termination of mRNA translation occurs when a stop codon enters the A site of the ribosome, and in eukaryotes is mediated by release factors eRF1 and eRF3, which form a ternary eRF1/eRF3-guanosine triphosphate (GTP) complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Translation release factor ERF1-ERF3 | down-regulates activity 
binding
|
80S_cytosolic_ribosome |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270817 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28368393 |
The essential ATP-binding cassette protein ABCE1 splits 80S ribosomes into 60S and 40S subunits after canonical termination or quality-control-based mRNA surveillance processes. Compared to the pre-splitting state, we observe repositioning of ABCE1's iron-sulfur cluster domain, which rotates 150° into a binding pocket on the 40S subunit. This repositioning explains a newly observed anti-association activity of ABCE1. Notably, the movement implies a collision with A-site factors, thus explaining the splitting mechanism. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Translation elongation and termination |
| + |
Translation release factor ERF1-ERF3 | up-regulates quantity 
chemical modification
|
protein polypeptide chain |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270818 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29735640 |
Termination of mRNA translation occurs when a stop codon enters the A site of the ribosome, and in eukaryotes is mediated by release factors eRF1 and eRF3, which form a ternary eRF1/eRF3–guanosine triphosphate (GTP) complex. eRF1 recognizes the stop codon, and after hydrolysis of GTP by eRF3, mediates release of the nascent peptide. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Translation elongation and termination |
| + |
ETF1 | form complex
binding
|
Translation release factor ERF1-ERF3 |
0.973 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270813 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29735640 |
Termination of mRNA translation occurs when a stop codon enters the A site of the ribosome, and in eukaryotes is mediated by release factors eRF1 and eRF3, which form a ternary eRF1/eRF3-guanosine triphosphate (GTP) complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
peptide | up-regulates activity
binding
|
Translation release factor ERF1-ERF3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270815 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29735640 |
Termination of mRNA translation occurs when a stop codon enters the A site of the ribosome, and in eukaryotes is mediated by release factors eRF1 and eRF3, which form a ternary eRF1/eRF3–guanosine triphosphate (GTP) complex. eRF1 recognizes the stop codon, and after hydrolysis of GTP by eRF3, mediates release of the nascent peptide. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Translation elongation and termination |
| + |
GTP | form complex
binding
|
Translation release factor ERF1-ERF3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275394 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29735640 |
Termination of mRNA translation occurs when a stop codon enters the A site of the ribosome, and in eukaryotes is mediated by release factors eRF1 and eRF3, which form a ternary eRF1/eRF3-guanosine triphosphate (GTP) complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Translation elongation and termination |
4.0
Translation release factor ERF1-ERF3
CPX-2721