| + |
D-glucopyranose | up-regulates quantity
precursor of
|
lactose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268474 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16157350 |
Beta-1,4-Galactosyltransferase-I (beta4Gal-T1) transfers galactose from UDP-galactose to N-acetylglucosamine (GlcNAc) residues of the branched N-linked oligosaccharide chains of glycoproteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAS1R2-TAS1R3 type 1 taste receptor complex | up-regulates activity
binding
|
lactose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281452 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40339580 |
The receptor, composed of two GPCR subunits, one unique (TAS1R2) and one shared with the umami receptor (TAS1R3), has the essential role of detecting and driving appetitive and consummatory responses to the most basic sources of metabolic energy (e.g., glucose, sucrose, lactose, and other sugars). Future studies determining the structure of the sweet receptor in the presence of sucrose, glucose, lactose, and other natural sugars will help uncover the nature of the interactions between the TAS1R2 VFT and sugars, further highlighting the evolutionary refinement and functional versatility of the binding pocket in accommodating such a wide range of millimolar-affinity ligands. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAS1R1-TAS1R3 type 1 taste receptor complex | up-regulates activity
binding
|
lactose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281455 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40339581 |
The receptor, composed of two GPCR subunits, one unique (TAS1R2) and one shared with the umami receptor (TAS1R3), has the essential role of detecting and driving appetitive and consummatory responses to the most basic sources of metabolic energy (e.g., glucose, sucrose, lactose, and other sugars). Future studies determining the structure of the sweet receptor in the presence of sucrose, glucose, lactose, and other natural sugars will help uncover the nature of the interactions between the TAS1R2 VFT and sugars, further highlighting the evolutionary refinement and functional versatility of the binding pocket in accommodating such a wide range of millimolar-affinity ligands. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Lactose synthase complex | up-regulates quantity
chemical modification
|
lactose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281021 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34125364 |
The lactose synthase complex is formed by B4GALT1 and LALBA in the Golgi, which then joins glucose and UDP-galactose to form lactose while the UMP moiety is recycled. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
UDP-D-galactose | up-regulates quantity
precursor of
|
lactose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268471 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16157350 |
Beta-1,4-Galactosyltransferase-I (beta4Gal-T1) transfers galactose from UDP-galactose to N-acetylglucosamine (GlcNAc) residues of the branched N-linked oligosaccharide chains of glycoproteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
B4GALT1 | up-regulates quantity
chemical modification
|
lactose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268469 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16157350 |
Beta-1,4-Galactosyltransferase-I (beta4Gal-T1) transfers galactose from UDP-galactose to N-acetylglucosamine (GlcNAc) residues of the branched N-linked oligosaccharide chains of glycoproteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |