| + |
TAS1R3 | form complex 
binding
|
TAS1R2-TAS1R3 type 1 taste receptor complex |
0.561 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281444 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40555359 |
The TAS1Rs include three members—TAS1R1, TAS1R2 and TAS1R3 (refs. 8,9)—that form heterodimers to mediate sweet (TAS1R2–TAS1R3 heterodimer) or umami (TAS1R1–TAS1R3 heterodimer) taste perception |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAS1R2 | form complex
binding
|
TAS1R2-TAS1R3 type 1 taste receptor complex |
0.561 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281445 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40555359 |
The TAS1Rs include three members—TAS1R1, TAS1R2 and TAS1R3 (refs. 8,9)—that form heterodimers to mediate sweet (TAS1R2–TAS1R3 heterodimer) or umami (TAS1R1–TAS1R3 heterodimer) taste perception |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAS1R2-TAS1R3 type 1 taste receptor complex | up-regulates activity 
binding
|
glucose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281448 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40339580 |
The receptor, composed of two GPCR subunits, one unique (TAS1R2) and one shared with the umami receptor (TAS1R3), has the essential role of detecting and driving appetitive and consummatory responses to the most basic sources of metabolic energy (e.g., glucose, sucrose, lactose, and other sugars). Future studies determining the structure of the sweet receptor in the presence of sucrose, glucose, lactose, and other natural sugars will help uncover the nature of the interactions between the TAS1R2 VFT and sugars, further highlighting the evolutionary refinement and functional versatility of the binding pocket in accommodating such a wide range of millimolar-affinity ligands. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAS1R2-TAS1R3 type 1 taste receptor complex | up-regulates activity
binding
|
sucrose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281450 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40339581 |
The receptor, composed of two GPCR subunits, one unique (TAS1R2) and one shared with the umami receptor (TAS1R3), has the essential role of detecting and driving appetitive and consummatory responses to the most basic sources of metabolic energy (e.g., glucose, sucrose, lactose, and other sugars). Future studies determining the structure of the sweet receptor in the presence of sucrose, glucose, lactose, and other natural sugars will help uncover the nature of the interactions between the TAS1R2 VFT and sugars, further highlighting the evolutionary refinement and functional versatility of the binding pocket in accommodating such a wide range of millimolar-affinity ligands. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAS1R2-TAS1R3 type 1 taste receptor complex | up-regulates activity
binding
|
lactose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281452 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40339580 |
The receptor, composed of two GPCR subunits, one unique (TAS1R2) and one shared with the umami receptor (TAS1R3), has the essential role of detecting and driving appetitive and consummatory responses to the most basic sources of metabolic energy (e.g., glucose, sucrose, lactose, and other sugars). Future studies determining the structure of the sweet receptor in the presence of sucrose, glucose, lactose, and other natural sugars will help uncover the nature of the interactions between the TAS1R2 VFT and sugars, further highlighting the evolutionary refinement and functional versatility of the binding pocket in accommodating such a wide range of millimolar-affinity ligands. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAS1R2-TAS1R3 type 1 taste receptor complex | up-regulates activity
binding
|
GNAS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281453 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40339580 |
The receptor, composed of two GPCR subunits, one unique (TAS1R2) and one shared with the umami receptor (TAS1R3), has the essential role of detecting and driving appetitive and consummatory responses to the most basic sources of metabolic energy (e.g., glucose, sucrose, lactose, and other sugars). From our density map and model, we identified two residues in TAS1R2—one in the third intracellular loop (Y756) and the other in the C-terminal tail (F827) that contact the G protein alpha subunit (Figure 6C). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
TAS1R2-TAS1R3 type 1 taste receptor complex