| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281478 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20354154 |
We find that human QTRTD1 (hQTRTD1) co-purifies with polyhistidine-tagged human QTRT1 (ht-hQTRT1) via Ni(2+) affinity chromatography. Cross-linking experiments, mass spectrometry, and size exclusion chromatography results are consistent with the two proteins existing as a heterodimer. Taken together, these results indicate that the human TGT is composed of a catalytic subunit, hQTRT1, and hQTRTD1, not USP14. hQTRTD1 has been implicated as the salvage enzyme that generates free queuine from QMP. |
|
4.0
queuosine 5'-phosphate(1-) residue
chemical modification