| + |
QTRT1 | form complex 
binding
|
TRNA-guanine transglycosylase complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281475 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20354154 |
We find that human QTRTD1 (hQTRTD1) co-purifies with polyhistidine-tagged human QTRT1 (ht-hQTRT1) via Ni(2+) affinity chromatography. Cross-linking experiments, mass spectrometry, and size exclusion chromatography results are consistent with the two proteins existing as a heterodimer. Taken together, these results indicate that the human TGT is composed of a catalytic subunit, hQTRT1, and hQTRTD1, not USP14. hQTRTD1 has been implicated as the salvage enzyme that generates free queuine from QMP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
QTRT2 | form complex
binding
|
TRNA-guanine transglycosylase complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281476 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20354154 |
We find that human QTRTD1 (hQTRTD1) co-purifies with polyhistidine-tagged human QTRT1 (ht-hQTRT1) via Ni(2+) affinity chromatography. Cross-linking experiments, mass spectrometry, and size exclusion chromatography results are consistent with the two proteins existing as a heterodimer. Taken together, these results indicate that the human TGT is composed of a catalytic subunit, hQTRT1, and hQTRTD1, not USP14. hQTRTD1 has been implicated as the salvage enzyme that generates free queuine from QMP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRNA-guanine transglycosylase complex | down-regulates quantity 
chemical modification
|
guanine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281477 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20354154 |
We find that human QTRTD1 (hQTRTD1) co-purifies with polyhistidine-tagged human QTRT1 (ht-hQTRT1) via Ni(2+) affinity chromatography. Cross-linking experiments, mass spectrometry, and size exclusion chromatography results are consistent with the two proteins existing as a heterodimer. Taken together, these results indicate that the human TGT is composed of a catalytic subunit, hQTRT1, and hQTRTD1, not USP14. hQTRTD1 has been implicated as the salvage enzyme that generates free queuine from QMP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRNA-guanine transglycosylase complex | down-regulates quantity
chemical modification
|
queuosine 5'-phosphate(1-) residue |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281478 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20354154 |
We find that human QTRTD1 (hQTRTD1) co-purifies with polyhistidine-tagged human QTRT1 (ht-hQTRT1) via Ni(2+) affinity chromatography. Cross-linking experiments, mass spectrometry, and size exclusion chromatography results are consistent with the two proteins existing as a heterodimer. Taken together, these results indicate that the human TGT is composed of a catalytic subunit, hQTRT1, and hQTRTD1, not USP14. hQTRTD1 has been implicated as the salvage enzyme that generates free queuine from QMP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRNA-guanine transglycosylase complex | up-regulates quantity 
chemical modification
|
guanosine 5'-monophosphate(1-) residue |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281479 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20354154 |
We find that human QTRTD1 (hQTRTD1) co-purifies with polyhistidine-tagged human QTRT1 (ht-hQTRT1) via Ni(2+) affinity chromatography. Cross-linking experiments, mass spectrometry, and size exclusion chromatography results are consistent with the two proteins existing as a heterodimer. Taken together, these results indicate that the human TGT is composed of a catalytic subunit, hQTRT1, and hQTRTD1, not USP14. hQTRTD1 has been implicated as the salvage enzyme that generates free queuine from QMP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRNA-guanine transglycosylase complex | up-regulates quantity
chemical modification
|
queuine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281480 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20354154 |
We find that human QTRTD1 (hQTRTD1) co-purifies with polyhistidine-tagged human QTRT1 (ht-hQTRT1) via Ni(2+) affinity chromatography. Cross-linking experiments, mass spectrometry, and size exclusion chromatography results are consistent with the two proteins existing as a heterodimer. Taken together, these results indicate that the human TGT is composed of a catalytic subunit, hQTRT1, and hQTRTD1, not USP14. hQTRTD1 has been implicated as the salvage enzyme that generates free queuine from QMP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
TRNA-guanine transglycosylase complex