Relation Results

Summary

Name L-isoprenaline
Synonyms (-)-Isoprenaline (ChemIDplus), (-)-Isoproterenol (ChemIDplus), (-)-N-Isopropylnoradrenaline (ChemIDplus), (R)-Isoprenaline (ChemIDplus), (R)-Isoproterenol (ChemIDplus), Isopropyl norepinephrine (ChemIDplus), L-(-)-Isoproterenol (ChemIDplus), l-Isoprenaline (ChemIDplus), L-Isoprenaline (KEGG COMPOUND), l-Isopropylnoradrenaline (ChemIDplus), l-Isoproterenol (ChemIDplus), Levisoprenalina (ChemIDplus), Levisoprenaline (KEGG COMPOUND), Levisoprenalinum (ChemIDplus)
IUPAC 4-[(1R)-1-hydroxy-2-(isopropylamino)ethyl]benzene-1,2-diol
Formula C11H17NO3
PRIMARY ID
(Read more)		 CHEBI:6257
Type chemical
Relations 3

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Type: Score: Layout: SPV 
0.80.80.8L-isoprenalineADRB2ADRB1ADRB3

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Regulator
Mechanism
target
score ℹ
+ L-isoprenalineup-regulates activity img/direct-activation.png chemical activation ADRB2 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-257457 Homo sapiens
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
+ L-isoprenalineup-regulates activity img/direct-activation.png chemical activation ADRB1 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-257456 Homo sapiens HEK-293A Cell
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
+ L-isoprenalineup-regulates activity img/direct-activation.png chemical activation ADRB3 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-257458 Homo sapiens HEK-293A Cell
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
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