Relation Results

Summary

Name tacedinaline
Synonyms 4-(Acetylamino)-N-(2-aminophenyl)benzamide (ChemIDplus), Acetyldinaline (ChemIDplus), C.I. 994 (ChemIDplus), CI 994 (ChemIDplus), CI-994 (ChemIDplus), N-acetyldinaline (ChEBI), tacedinalina (ChemIDplus), tacedinaline (KEGG COMPOUND)
IUPAC 4-acetamido-N-(2-aminophenyl)benzamide
Formula C15H15N3O2
PRIMARY ID
(Read more)		 CHEBI:90195
Type chemical
Relations 3

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Type: Score: Layout: SPV 
0.80.80.8tacedinalineHDAC1HDAC2HDAC3

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Relations
Regulator
Mechanism
target
score ℹ
+ tacedinalinedown-regulates activity img/direct_inhibition.png chemical inhibition HDAC1 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-258009 in vitro
pmid sentence
Collaboratively, we synthesized and assembled a panel of structurally-diverse small-molecule HDACi 1, 2, 7-20 that comprise most of the relevant literature-reported tool compounds and pharmaceutically developed clinical candidates (Supplementary Fig 3). We next conducted a high-throughput, precise profiling of HDACi potency against all Class I and II enzymes, in a miniaturized dose-ranging format (Supplementary Table 1).
Publications: 1 Organism: In Vitro
+ tacedinalinedown-regulates activity img/direct_inhibition.png chemical inhibition HDAC2 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-258008 in vitro
pmid sentence
Collaboratively, we synthesized and assembled a panel of structurally-diverse small-molecule HDACi 1, 2, 7-20 that comprise most of the relevant literature-reported tool compounds and pharmaceutically developed clinical candidates (Supplementary Fig 3). We next conducted a high-throughput, precise profiling of HDACi potency against all Class I and II enzymes, in a miniaturized dose-ranging format (Supplementary Table 1).
Publications: 1 Organism: In Vitro
+ tacedinalinedown-regulates activity img/direct_inhibition.png chemical inhibition HDAC3 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-258007 in vitro
pmid sentence
Collaboratively, we synthesized and assembled a panel of structurally-diverse small-molecule HDACi 1, 2, 7-20 that comprise most of the relevant literature-reported tool compounds and pharmaceutically developed clinical candidates (Supplementary Fig 3). We next conducted a high-throughput, precise profiling of HDACi potency against all Class I and II enzymes, in a miniaturized dose-ranging format (Supplementary Table 1).
Publications: 1 Organism: In Vitro
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